Scientist / Sr. Scientist Posted Aug 24
Genomatica , San Diego, CA
Title: Scientist / Senior Research Scientist
Department: Analytical

Position Summary

Genomatica develops commercial biobased processes to make widely-used chemicals that enable better, more sustainable everyday products. That enables our partners and leading brands to offer better food packaging, auto parts, clothing, tires, carpets, and more.

We’ve commercialized processes for bio-BDO (for plastics) and for biobased butylene glycol (for cosmetics); and our technology drives the world’s first commercial-scale biobased plant for a major intermediate chemical. We’re working on polyamide intermediates (nylon) and on butadiene (tires); and we’re helping numerous companies with their bioprocesses. We have more on the way.

Genomatica is seeking a Research Scientist / Sr. Research Scientist with experience in analytical chemistry to work as a member of the Analytical Sciences team. The Analytical team is responsible for quantitative and qualitative analysis of fermentation and other types of samples using a variety of chromatographic, mass spectrometric and spectroscopic techniques, including LCMS, HRAM LCMS, GC/GCMS, HPLC-UV-RID, Ion Chromatography, ultimately helping develop cost-advantaged production of chemicals using microorganisms. The successful candidate will utilize her/his knowledge of a wide variety of analytical chemistry techniques to support and help advance Genomatica strain engineering and process technology platforms.

Essential Functions and Responsibilities include the following. Other duties may be assigned. To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Method development and analysis of small molecules utilizing Sciex QQQ LCMS for accurate quantitation and Thermo QE HR LCMS for metabolomics
Targeted and untargeted analysis and identification of unknowns
High-throughput LCMS/MS analysis with high precision and accuracy to support strain engineering and fermentation process development
Development of automated HTP sample preparation platform
LCMS instrument maintenance and troubleshooting
Data analysis, interpretation and communication to project and functional teams
Leading analytical support and development for specific projects, as assigned.

Qualifications & Experience

The requirements listed below are representative of the knowledge, skill, and/or ability required in order satisfactorily perform in this role.


Degree in Analytical chemistry, Chemistry, Biochemistry or related fields. BS, MS and PhD candidates will be considered with minimum 2-5 years of experience in biotechnology industry, preferably in the field of renewable chemicals and energy processes.


Expertise and broad advanced knowledge of chromatography, mass spectrometry, spectroscopy and other analytical techniques. Specifically, experimental proficiency and proven records of method development and problem solving utilizing LCMS and HR LCMS, including QQQ and Orbitrap platforms, are required. Focus on small molecule and metabolite analysis.
Proficiency in LCMS instrument troubleshooting and maintenance.
Experience with HTP analytical experimentation, automated liquid handling robotics and sample preparation platforms.
Familiarity with fermentation based technology and metabolic engineering basics.
Advanced computer skills for data processing, familiarization with Analyst, Xcalibur and Chromeleon software platforms.
Excellent organization and communication skills, written and oral.
Great team player.

Knowledge Requirements

Proficiency in separation based analytical chemistry, liquid chromatography, gas chromatography, mass spectrometry.
Advanced knowledge of chromatography and mass spectrometry fundamentals, chemistry, compound characterization and identification, and method development expertise. Experience in setting up HTP methods. Proven records of successful analytical implementations.
Proficiency and knowledge of Thermo and Sciex LCMS instruments and software.
Proven record of success in new analytical development and implementation


Excellent organization, prioritization, time management and attention to detail
Excellent written and oral communication skills
Ability to interact comfortably and professionally with all levels of the organization and external customers
Team player committed to success and getting the job done well
Technological literacy with an emphasis on Microsoft Excel, Outlook and PowerPoint
Approachable, solutions-oriented and able to maintain composure
Desire to learn new things, positive attitude and enthusiasm

Work Environment/ Physical Demands

The work environment and physical demands described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

This position involves working primarily in a laboratory setting. As such this position requires the ability to stand or sit at the bench, the use of standard laboratory equipment as well as computers and office equipment. The position requires communication with other individuals through a variety of methods

Genomatica is committed to providing exciting career opportunities in an environment that values trust, respect, openness, teamwork, creativity, enthusiasm, and diligence. We strive to create a culture that enables and encourages everyone to bring their whole selves to work. We are committed to be a company where everyone feels they have equal opportunity to reach their potential. Everyone is accepted and appreciated for who they are and what they bring to Genomatica.

We promote the continued development of an inclusive environment that values diversity through Geno4All, our employee led Diversity, Equity, and Inclusion (DEI) committee. We are looking for innovative, highly motivated, and collaborative people who enjoy the challenges and rewards of a company devoted to commercializing cutting-edge sustainable technology.

Check us out on our LinkedIn Life page. Genomatica is an equal opportunity employer.

Qualified applicants will be considered without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability or any other characteristic protected by law.

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